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PT-141
Peptide appearance Lyophilized form

Melanocortin research peptide

PT-141

In stock

A cyclic melanocortin analogue used in controlled receptor-signalling and peptide-development research.

Available strengths
38,50 
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PT-141

38,50 

Cyclic melanocortin analogue for MC3R, MC4R, and receptor-selectivity studies.

Research overview

PT-141

PT-141 is the catalogue name for bremelanotide, a cyclic synthetic peptide associated with melanocortin-receptor research. Its constrained peptide design distinguishes it from linear melanocortin sequence references and supports controlled structure-and-signalling comparisons.

The authoritative database records establish compound identity, and the cited development report documents bremelanotide across a structured research programme. This literature supplies receptor-family and development context without defining a use or expected result for the product; the selected lot remains subject to its exact product record and signed analytical certificate.

Compound information

Specifications

Molecular profile

Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular mass
1025.2 g/mol
CAS number
189691-06-3
Molecular formula
C50H68N14O10

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Synthetic cyclic melanocortin analogue; studied for central melanocortin receptor signalling and neuroendocrine pathway research; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Tests

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 10mg

Certificate preview for 10mg

99.8%Purity by HPLC

Batch number
20267121
Tested
2026-09-08

Recorded QC panel

AssayPeptide Screening 0.1% TFA
13.51 mg (± 0.07 mg)
PurityPeptide Screening 0.1% TFA
99.8%
Identity (FTIR)Peptide Screening 0.1% TFA
994 (± 5)
Identity (RT)Retention time
0.997 (± 0.005)
Bacterial endotoxinUSP 85 / Eur. Ph. 2.6.14
0.010 EU/mg

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: Bremelanotide

Authoritative identity record for the compound sold under the PT-141 catalogue name.

PubChem · View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 189691-06-3

Authoritative CAS Registry Number record for bremelanotide/PT-141.

CAS Common Chemistry · View source ↗

Clayton AH, Kingsberg SA, Portman D, et al. · 2022

Safety Profile of Bremelanotide Across the Clinical Development Program

Primary clinical-development report for bremelanotide.

Journal of Women's Health · 10.1089/jwh.2021.0191 View source ↗

National Center for Biotechnology Information

PubChem compound record

PubChem · View source ↗

Kingsberg SA, Clayton AH, Portman D, Williams LA, Krop J, Jordan R, Lucas J, Simon JA · 2019

Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials

Obstetrics and gynecology · View source ↗

Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY · 2003

PT-141: a melanocortin agonist for the treatment of sexual dysfunction

Annals of the New York Academy of Sciences · View source ↗

Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R · 2006

An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist

The journal of sexual medicine · View source ↗

Edinoff AN, Sanders NM, Lewis KB, Apgar TL, Cornett EM, Kaye AM, Kaye AD · 2022

Bremelanotide for Treatment of Female Hypoactive Sexual Desire

Neurology international · View source ↗

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