Peptide appearance
Lyophilized form helps protect peptide quality. Peptides are supplied as a dry powder, which may look like a compact "puck" or a lighter powder inside the vial.
Because the peptide is dry, it does not require refrigerated shipping during normal transit, including warm seasonal conditions. For longer storage, follow the storage guidance in the product description.
Appearance can vary. The stated peptide content is checked through third-party analysis.
Read more in the product description.
Solution not bundled
Peptides are delivered as lyophilized powder. This dry form helps preserve peptide quality during storage and transport and does not require refrigerated shipping during normal transit.
To prepare a solution, use a solvent such as Bacteriostatic water. It is sold separately, so add it only when you need it for peptide preparation.
Read more in the product description.
Signalling tripeptide
KPV
Low stock
KPV is the three-amino-acid Lys-Pro-Val fragment linked to alpha-MSH research. Published studies look at cell transport, cytokine signals, wound models, scar formation, and receptor-related questions.
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KPV
38,50 €
KPV tripeptide fragment for melanocortin, barrier, and immune-signalling studies.
Research overview
KPV
KPV is a short, defined fragment, not the complete alpha-MSH peptide. This difference matters when transport, receptor, and stability studies are compared.
Studies cover intestinal cell models, inflammation markers, wound-related tests, and alpha-MSH comparisons. They identify research endpoints but do not promise a result for this material.
Cell transport and signalling
Studies use epithelial-cell systems to measure KPV uptake, transporter activity, NF-kB-related signals, and cytokines. These are controlled laboratory questions.
Other work compares KPV with alpha-MSH pathways, where sequence length and receptor context matter.
Tissue-model endpoints
Published work also uses wound and scar-formation models. Cell movement, matrix, and inflammation measurements apply only to the original model.
Compound information
Specifications
Molecular profile
- Sequence
- Lys-Pro-Val
- Molecular mass
- 342.43 g/mol
- CAS number
- 67727-97-3
- Molecular formula
- C16H30N4O4
Material record
- Physical appearance
- White to off-white lyophilized powder
- Solubility
- Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
- Product note
- Alpha-MSH tripeptide fragment; supplied strictly for research use only.
Laboratory care
Handling
Peptides in transport
Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.
Storage of lyophilized peptides
Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:
- Room temperature (15–25 °C): Up to 3 months
- Refrigerated (2–8 °C): Up to 6 months
- Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)
Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.
Storage of reconstituted peptides
Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.
The following storage conditions are generally recommended:
- Room temperature (15–25 °C): Avoid prolonged storage
- Refrigerated (2–8 °C): Typically 4–8 weeks
- Frozen (-20 °C or below): Up to 3–4 months
To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.
Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.
Analytical documentation
Tests
Latest published result
Liquilabs s.r.o.Signed Certificate of Analysis · 10mg
> 99.8%Purity by HPLC
Recorded QC panel
- AssayPeptide Screening 0.1% TFA
- 10.48 mg (± 0.05 mg)
- PurityPeptide Screening 0.1% TFA
- > 99.8%
- Identity (FTIR)Peptide Screening 0.1% TFA
- 995 (± 5)
- Identity (RT)Retention time
- 0.984 (± 0.005)
- Bacterial endotoxinUSP 85 / Eur. Ph. 2.6.14
- 0.157 EU/mg
These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.
Source record
References
National Center for Biotechnology Information
PubChem Compound Summary: Lys-Pro-Val
Authoritative identity record for the KPV tripeptide.
PubChem · View source ↗Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. · 2008
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Primary study of KPV transport and signalling in an experimental model.
Gastroenterology · 10.1053/j.gastro.2007.10.026 View source ↗Chemical Abstracts Service
CAS Common Chemistry: 67727-97-3
Authoritative CAS Registry Number record for KPV.
CAS Common Chemistry · View source ↗National Center for Biotechnology Information
PubChem compound record
PubChem · View source ↗Luger TA, Brzoska T · 2007
alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs
Annals of the rheumatic diseases · View source ↗Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D · 2017
Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis
Molecular therapy : the journal of the American Society of Gene Therapy · 10.1016/j.ymthe.2016.1020 View source ↗M. E. Hiltz and J. M. Lipton · 1989
Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH
FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol ·K. Kannengiesser et al. · 2008
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Inflamm. Bowel Dis · 10.1002/ibd.20334 View source ↗D. B. Richards and J. M. Lipton · 1984
Effect of alpha-MSH 11-13 (lysine-proline-valine) on fever in the rabbit
Peptides · 10.1016/0196-9781(84)90027-5 View source ↗T. Brzoska, T. A. Luger, C. Maaser, C. Abels, and M. Böhm · 2008
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases
Endocr. Rev · 10.1210/er.2007-0027 View source ↗T. A. Luger and T. Brzoska · 2007
α‐MSH related peptides: a new class of anti‐inflammatory and immunomodulating drugs
Ann. Rheum. Dis · 10.1136/ard.2007.079780 View source ↗M. Cutuli, S. Cristiani, J. M. Lipton, and A. Catania · 2000
Antimicrobial effects of alpha-MSH peptides
J. Leukoc. Biol · 10.1002/jlb.67.2.233 View source ↗M. F. Masman et al. · 2006
Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties
Bioorg. Med. Chem · 10.1016/j.bmc.2006.07.007 View source ↗K. S. de Souza et al. · 2015
Improved cutaneous wound healing after intraperitoneal injection of alpha-melanocyte-stimulating hormone
Exp. Dermatol · 10.1111/exd.12609 View source ↗C. Lonati et al. · 2013
Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats
Peptides · 10.1016/j.peptides.2013.10.014 View source ↗G. Colombo et al. · 1950
Gene expression profiling reveals multiple protective influences of the peptide alpha-melanocyte-stimulating hormone in experimental heart transplantation
J. Immunol. Baltim. Md 1950 · 10.4049/jimmunol.175.5.3391 View source ↗G. Colombo et al. · 2007
Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury
Shock Augusta Ga · 10.1097/01.shk.0000239764.80033.7e View source ↗M. Schiller et al. · 2001
Human Dermal Fibroblasts Express Prohormone Convertases 1 and 2 and Produce Proopiomelanocortin-Derived Peptides
J. Invest. Dermatol · 10.1046/j.0022-202x.2001.01412.x View source ↗T. Brzoska, M. Böhm, A. Lügering, K. Loser, and T. A. Luger · 2010
Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore
Adv. Exp. Med. Biol · 10.1007/978-1-4419-6354-3_8 View source ↗S. J. Getting, H. B. Schiöth, and M. Perretti · 2003
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides
J. Pharmacol. Exp. Ther · 10.1124/jpet.103.051623 View source ↗K. Pawar, C. S. Kolli, V. K. Rangari, and R. J. Babu · 2017
Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin
J. Pharm. Sci · 10.1016/j.xphs.2017.03.017 View source ↗Customer reviews
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