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Peptide appearance Lyophilized form

Signalling tripeptide

KPV

Low stock

KPV is the three-amino-acid Lys-Pro-Val fragment linked to alpha-MSH research. Published studies look at cell transport, cytokine signals, wound models, scar formation, and receptor-related questions.

Available strengths
38,50 
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KPV

38,50 

KPV tripeptide fragment for melanocortin, barrier, and immune-signalling studies.

SKU: ADRIA-KPV Category:

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Research overview

KPV

KPV is a short, defined fragment, not the complete alpha-MSH peptide. This difference matters when transport, receptor, and stability studies are compared.

Studies cover intestinal cell models, inflammation markers, wound-related tests, and alpha-MSH comparisons. They identify research endpoints but do not promise a result for this material.

Cell transport and signalling

Studies use epithelial-cell systems to measure KPV uptake, transporter activity, NF-kB-related signals, and cytokines. These are controlled laboratory questions.

Other work compares KPV with alpha-MSH pathways, where sequence length and receptor context matter.

Tissue-model endpoints

Published work also uses wound and scar-formation models. Cell movement, matrix, and inflammation measurements apply only to the original model.

Compound information

Specifications

Molecular profile

Sequence
Lys-Pro-Val
Molecular mass
342.43 g/mol
CAS number
67727-97-3
Molecular formula
C16H30N4O4

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Alpha-MSH tripeptide fragment; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 10mg

Certificate preview for 10mg

> 99.8%Purity by HPLC

Batch number
2027602
Tested
2026-09-08

Recorded QC panel

AssayPeptide Screening 0.1% TFA
10.48 mg (± 0.05 mg)
PurityPeptide Screening 0.1% TFA
> 99.8%
Identity (FTIR)Peptide Screening 0.1% TFA
995 (± 5)
Identity (RT)Retention time
0.984 (± 0.005)
Bacterial endotoxinUSP 85 / Eur. Ph. 2.6.14
0.157 EU/mg

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: Lys-Pro-Val

Authoritative identity record for the KPV tripeptide.

PubChem · View source ↗

Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. · 2008

PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation

Primary study of KPV transport and signalling in an experimental model.

Gastroenterology · 10.1053/j.gastro.2007.10.026 View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 67727-97-3

Authoritative CAS Registry Number record for KPV.

CAS Common Chemistry · View source ↗

National Center for Biotechnology Information

PubChem compound record

PubChem · View source ↗

Luger TA, Brzoska T · 2007

alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs

Annals of the rheumatic diseases · View source ↗

Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D · 2017

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

Molecular therapy : the journal of the American Society of Gene Therapy · 10.1016/j.ymthe.2016.1020 View source ↗

M. E. Hiltz and J. M. Lipton · 1989

Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH

FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol ·

K. Kannengiesser et al. · 2008

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

Inflamm. Bowel Dis · 10.1002/ibd.20334 View source ↗

D. B. Richards and J. M. Lipton · 1984

Effect of alpha-MSH 11-13 (lysine-proline-valine) on fever in the rabbit

Peptides · 10.1016/0196-9781(84)90027-5 View source ↗

T. Brzoska, T. A. Luger, C. Maaser, C. Abels, and M. Böhm · 2008

Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases

Endocr. Rev · 10.1210/er.2007-0027 View source ↗

T. A. Luger and T. Brzoska · 2007

α‐MSH related peptides: a new class of anti‐inflammatory and immunomodulating drugs

Ann. Rheum. Dis · 10.1136/ard.2007.079780 View source ↗

M. Cutuli, S. Cristiani, J. M. Lipton, and A. Catania · 2000

Antimicrobial effects of alpha-MSH peptides

J. Leukoc. Biol · 10.1002/jlb.67.2.233 View source ↗

M. F. Masman et al. · 2006

Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties

Bioorg. Med. Chem · 10.1016/j.bmc.2006.07.007 View source ↗

K. S. de Souza et al. · 2015

Improved cutaneous wound healing after intraperitoneal injection of alpha-melanocyte-stimulating hormone

Exp. Dermatol · 10.1111/exd.12609 View source ↗

C. Lonati et al. · 2013

Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats

Peptides · 10.1016/j.peptides.2013.10.014 View source ↗

G. Colombo et al. · 1950

Gene expression profiling reveals multiple protective influences of the peptide alpha-melanocyte-stimulating hormone in experimental heart transplantation

J. Immunol. Baltim. Md 1950 · 10.4049/jimmunol.175.5.3391 View source ↗

G. Colombo et al. · 2007

Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury

Shock Augusta Ga · 10.1097/01.shk.0000239764.80033.7e View source ↗

M. Schiller et al. · 2001

Human Dermal Fibroblasts Express Prohormone Convertases 1 and 2 and Produce Proopiomelanocortin-Derived Peptides

J. Invest. Dermatol · 10.1046/j.0022-202x.2001.01412.x View source ↗

T. Brzoska, M. Böhm, A. Lügering, K. Loser, and T. A. Luger · 2010

Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore

Adv. Exp. Med. Biol · 10.1007/978-1-4419-6354-3_8 View source ↗

S. J. Getting, H. B. Schiöth, and M. Perretti · 2003

Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides

J. Pharmacol. Exp. Ther · 10.1124/jpet.103.051623 View source ↗

K. Pawar, C. S. Kolli, V. K. Rangari, and R. J. Babu · 2017

Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin

J. Pharm. Sci · 10.1016/j.xphs.2017.03.017 View source ↗

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