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Peptide appearance Lyophilized form

Metabolic peptide

GLP-3 (RT)

Low stock

GLP-3 is Adria Science's catalogue name for retatrutide. This synthetic peptide is studied at GIP, GLP-1, and glucagon receptors.

Available strengths
168,50 
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GLP-3 (RT)

Price range: 77,90 € through 168,50 €

Triple incretin analogue for GLP-1, GIP, and glucagon receptor pathway studies.

SKU: ADRIA-GLP3 Category:

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Research overview

GLP-3 (RT)

Retatrutide, also called LY3437943, is one engineered peptide that can signal through three receptor pathways. Its design is different from a blend of separate peptides.

Studies measure receptor activity, glucose-related signals, fat-tissue endpoints, and liver models. These controlled findings do not promise a result for the supplied material.

Triple-receptor pharmacology

Studies measure activity at GIP, GLP-1, and glucagon receptors. They also examine sequence design and albumin binding.

The three pathways are not interchangeable. Comparisons must use the exact assay and activity values from the original study.

Metabolic and liver models

Published work also covers glucose, lipid, energy-balance, and liver-related measurements. These findings do not replace lot-specific analytical testing.

Compound information

Specifications

Molecular profile

Sequence
Y-Aib-QGTFTSDYSI-alphaMeLeu-LDKK(AEEA-gamma-Glu-C20 diacid)-AQAibAFIEYLLEGGPSSGAPPPS-NH2
Molecular mass
4731.4 g/mol
CAS number
2381089-83-2
Molecular formula
C221H342N46O68

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
GLP-3 research compound; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 30mg

99.8%Purity by HPLC

Batch number
3908019
Tested
2026-07-27

Recorded QC panel

AssayPeptide screening
30.0 mg
PurityPeptide screening
99.8%
Identity (FTIR)FTIR spectrum
994
Identity (RT)Retention time
0.996
Bacterial EndotoxinUSP / Eur. Ph. 2.6.14
0.008 EU/mg
Molecular Ion MassMS deconvolution
4731 Da

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

Coskun T, Urva S, Roell WC, et al. · 2022

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept

Discovery, molecular design, and receptor characterisation of LY3437943.

Cell Metabolism · 10.1016/j.cmet.2022.07.013 View source ↗

Jastreboff AM, Kaplan LM, Frías JP, et al. · 2023

Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

Clinical research report concerning the compound described as retatrutide.

The New England Journal of Medicine · 10.1056/nejmoa2301972 View source ↗

National Center for Biotechnology Information

PubChem Compound Summary: Retatrutide

Authoritative identity record for retatrutide, also described as LY3437943.

PubChem · View source ↗

Goldney J, Hamza M, Surti F, Davies MJ, Papamargaritis D · 2025

Triple Agonism Based Therapies for Obesity

Current cardiovascular risk reports · View source ↗

Katsi V, Koutsopoulos G, Fragoulis C, Dimitriadis K, Tsioufis K · 2025

Retatrutide-A Game Changer in Obesity Pharmacotherapy

Biomolecules · View source ↗

Abdrabou Abouelmagd A, Abdelrehim AM, Bashir MN, Abdelsalam F, Marey A, Tanas Y, Abuklish DM, Belal MM · 2025

Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials

Proceedings (Baylor University. Medical Center) · View source ↗

· 2025

Retatrutide (LY3437943): A Novel Tri-agonist Peptide for Metabolic Disease Treatment

2025 ·

Alaa Abdrabou Abouelmagd et al. · 2025

Efficacy and safety of retatrutide, a novel GLP-1, GIP, and GCG receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials

2025 ·

· 2024

Sanyal AJ, Kaplan LM, Frias JP, et al. Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial. Nat Med. 2024;30(7):2037–2048. doi: 10.1038/s41591-024-03018-2. [DOI] [PMC free article] [PubMed] [Google Scholar]

· 10.1038/s41591-024-03018-2 View source ↗

· 2023

Rosenstock J, Frias J, Jastreboff AM, et al. Retatrutide, a GIP, GLP-1 and GCG receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. Lancet. 2023;402(10401):529–544. doi: 10.1016/S0140-6736(23)01053-X. [DOI] [PubMed]

· 10.1016/s0140-6736(23)01053-x View source ↗

· 2022

Urva S, Coskun T, Loh MT, et al. LY3437943, a novel triple GIP, GLP-1, and GCG receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial. Lancet. 2022;400(10366):1869–1881. doi: 10.1016/S0140-6736(22)02033-5. [DOI] [PubMed]

· 10.1016/s0140-6736(22)02033-5 View source ↗

Customer reviews

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