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Peptide appearance Lyophilized form

Copper peptide

GHK-CU

In stock

GHK-Cu is the copper complex of the peptide glycyl-L-histidyl-L-lysine. Published studies look at copper binding, extracellular matrix, microbes, nerve cells, and gene expression.

Available strengths
62,00 
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GHK-CU

Price range: 38,50 € through 62,00 €

GHK-Cu copper peptide complex for matrix, copper-signalling, and remodeling studies.

SKU: ADRIA-GHK-CU Category:

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Research overview

GHK-CU

GHK-Cu combines a defined three-amino-acid peptide with copper. Its complex form, copper binding, and analytical identity matter when studies are compared.

Studies cover matrix-related cell work, microbial tests, nervous-system models, and gene activity. They provide research context, not a promised result for this material.

Copper binding and matrix models

Studies measure copper binding, fibroblast activity, collagen markers, and extracellular-matrix signals. These topics support controlled chemistry and cell-culture work.

Gene-expression studies must be read with their exact tissue, timepoint, and test method.

Microbial and neural research

Other studies use microbial tests and nervous-system models. These model types should be read separately instead of combined into one broad claim.

Compound information

Specifications

Molecular profile

Sequence
Gly-His-Lys
Molecular mass
401.91 g/mol
CAS number
89030-95-5
Molecular formula
C14H22CuN6O4

Material record

Physical appearance
Blue to blue-green lyophilized powder
Salt form
1:1 GHK–Cu(II) complex
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Copper-binding tripeptide complex; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 100mg

> 99.8%Purity by HPLC

Batch number
2441235
Tested
2026-07-27

Recorded QC panel

AssayPeptide screening
89.4 mg
PurityPeptide screening
> 99.8%
Identity (FTIR)FTIR spectrum
987
Identity (RT)Retention time
0.991
Bacterial EndotoxinUSP / Eur. Ph. 2.6.14
0.002 EU/mg
Molecular Ion MassMS deconvolution
341 g/mol

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

Badenhorst T, Svirskis D, Merrilees MJ, et al. · 2016

Physicochemical characterization of native glycyl-l-histidyl-l-lysine tripeptide for wound healing and anti-aging: a preformulation study for dermal delivery

Physicochemical and stability characterisation of GHK-Cu.

Pharmaceutical Development and Technology · 10.3109/10837450.2014.979944 View source ↗

National Center for Biotechnology Information

PubChem Compound Summary: GHK-Cu

Authoritative identity record for the GHK-Cu copper-peptide complex.

PubChem · View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 49557-75-7

Authoritative CAS Registry Number record for GHK-Cu.

CAS Common Chemistry · View source ↗

National Center for Biotechnology Information

PubChem compound record

PubChem · View source ↗

Pickart L, Margolina A · 2018

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

International journal of molecular sciences · View source ↗

Pickart L, Vasquez-Soltero JM, Margolina A · 2015

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

BioMed research international · View source ↗

A. Gruchlik, E. Chodurek, and Z. Dzierzewicz · 2014

Effect of GLY-HIS-LYS and its copper complex on TGF-β secretion in normal human dermal fibroblasts

Acta Pol. Pharm ·

X. Wang et al. · 2017

GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis

Wound Repair Regen. Off. Publ. Wound Heal. Soc. Eur. Tissue Repair Soc ·

M. Kukowska, M. Kukowska-Kaszuba, and K. Dzierzbicka · 2015

In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections

Bioorg. Med. Chem. Lett ·

G. D. Mulder et al. · 1994

Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-l-histidyl-l-lysine copper

Wound Repair Regen. Off. Publ. Wound Heal. Soc. Eur. Tissue Repair Soc ·

S. O. Canapp et al. · 2003

The effect of topical tripeptide-copper complex on healing of ischemic open wounds

Vet. Surg. VS ·

L. Pickart, J. M. Vasquez-Soltero, and A. Margolina · 2017

The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline

Brain Sci ·

H. Zhang, Y. Wang, and Z. He · 2018

Glycine-Histidine-Lysine (GHK) Alleviates Neuronal Apoptosis Due to Intracerebral Hemorrhage via the miR-339-5p/VEGFA Pathway

Front. Neurosci ·

X.-M. Zhou et al. · 2017

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition

Front. Pharmacol ·

J.-R. Park, H. Lee, S.-I. Kim, and S.-R. Yang · 2016

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice

Oncotarget ·

L. А. Sever'yanova and M. E. Dolgintsev · 2017

Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats

Bull. Exp. Biol. Med ·

L. А. Sever'yanova and D. V. Plotnikov · 2018

Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects

Bull. Exp. Biol. Med ·

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