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Peptide appearance Lyophilized form

Neuroregulatory peptide

DSIP

In stock

DSIP is a peptide made of nine amino acids. Published studies look at brain signals, metabolism, low-oxygen models, and receptor-related measurements.

Available strengths
55,50 
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DSIP

55,50 

Delta sleep-inducing peptide for neuropeptide, circadian, and stress-pathway studies.

SKU: ADRIA-DSIP Category:

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Research overview

DSIP

DSIP means delta sleep-inducing peptide and refers to a defined nine-amino-acid sequence. Its short sequence supports controlled identity and signalling studies.

Studies include brain recordings, pain-model endpoints, metabolism, low-oxygen conditions, and cell growth. Each report applies only to its own laboratory system.

Brain-signal and receptor studies

Studies examine EEG-related observations and opioid- and GABA-related signalling. They also measure behaviour and brain chemistry in controlled models.

The original study explains what was measured and what its limits are.

Metabolic and cellular models

Other work covers low-oxygen, metabolic, muscle, and cell-growth models. Exact sequence, controls, and test conditions are important when comparing these different studies.

Compound information

Specifications

Molecular profile

Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular mass
848.82 g/mol
CAS number
62568-57-4
Molecular formula
C35H48N10O15

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Delta sleep-inducing peptide; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 10mg

Certificate preview for 10mg

99.7%Purity by HPLC

Batch number
2028399
Tested
2026-09-08

Recorded QC panel

AssayPeptide Screening 0.1% TFA
14.13 mg (± 0.07 mg)
PurityPeptide Screening 0.1% TFA
99.7%
Identity (FTIR)Peptide Screening 0.1% TFA
983 (± 5)
Identity (RT)Retention time
0.992 (± 0.005)
Bacterial endotoxinUSP 85 / Eur. Ph. 2.6.14
0.335 EU/mg

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: Delta sleep-inducing peptide

Authoritative identity record for DSIP.

PubChem · View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 62568-57-4

Authoritative CAS Registry Number record for DSIP.

CAS Common Chemistry · View source ↗

Schoenenberger GA, Monnier M · 1977

Characterization of a delta-electroencephalogram (delta-sleep)-inducing peptide

Primary characterisation report for DSIP.

Proceedings of the National Academy of Sciences of the United States of America · 10.1073/pnas.74.3.1282 View source ↗

Sukhanova TV, Artyukhov AA, Gurevich YM · 2014

Delta-sleep inducing peptide entrapment in the charged macroporous matrices

Primary materials study using DSIP.

Materials Science and Engineering C · 10.1016/j.msec.2014.05.059 View source ↗

National Center for Biotechnology Information

PubChem compound record

PubChem · View source ↗

Schaison G, Jacquillat Cl, Weil M, Auclerc MJ, Curely JP, Bernard J · 1977

[Recurrence with gonadic localization of acute leukemia. 113 cases]

La Nouvelle presse medicale · View source ↗

Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA · 1981

Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior

International journal of clinical pharmacology, therapy, and toxicology · View source ↗

Bes F, Hofman W, Schuur J, Van Boxtel C · 1992

Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study

Neuropsychobiology · View source ↗

Dick P, Costa C, Fayolle K, Grandjean ME, Khoshbeen A, Tissot R · 1984

DSIP in the treatment of withdrawal syndromes from alcohol and opiates

European neurology · View source ↗

Larbig W, Gerber WD, Kluck M, Schoenenberger GA · 1984

Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study

European neurology · View source ↗

Schneider-Helmert D, Schoenenberger GA · 1983

Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep

Neuropsychobiology · View source ↗

Yehuda S, Carasso RL · 1988

DSIP--a tool for investigating the sleep onset mechanism: a review

The International journal of neuroscience · View source ↗

Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, Slashcheva GA, Prudchenko IA, Mikhaleva II, Khokhlova ON, Murashev AN, Ivanov VT · 2021

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

Molecules (Basel, Switzerland) · View source ↗

· 2019

The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep

· 10.1007/bf01971753 View source ↗

· 2019

Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia

· View source ↗

· 2019

Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP)

· View source ↗

· 2019

Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypo

· View source ↗

· 2019

Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress

· View source ↗

· 2019

Decreased concentrations of delta-sleep inducing peptide in plasma and cerebrospinal fluid from depressed patients: Nordisk Psykiatrisk Tidsskrift: Vol 39, No sup11

· 10.3109/08039488509101959 View source ↗

· 2019

Delta sleep-inducing peptide (DSIP): An overview of central actions and possible relationship to psychiatric illnesses: Nordisk Psykiatrisk Tidsskrift: Vol 42, No 2

· 10.3109/08039488809103215 View source ↗

· 2019

High delta sleep-inducing peptide-like immunoreactivity in plasma in suicidal patients with major depressive disorder

· View source ↗

· 2019

Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial

· View source ↗

· 2019

Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female

· View source ↗

A. B. Sinyukhin, G. P. Timoshinov, V. A. Kornilov, and P. D. Shabanov · 2009

P.7.a.006 Delta sleep-inducing peptide analogue corrects the CNS functional state of children treated with antiblastomic therapy

Eur. Neuropsychopharmacol ·

E. V. Koplik et al. · 2008

Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection

Neurosci. Behav. Physiol ·

· 2019

[DSIP: the sleep peptide or an unknown hypothalamic hormone?]

· View source ↗

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