
Peptide appearance
Lyophilized form helps protect peptide quality. Peptides are supplied as a dry powder, which may look like a compact "puck" or a lighter powder inside the vial.
Because the peptide is dry, it does not require refrigerated shipping during normal transit, including warm seasonal conditions. For longer storage, follow the storage guidance in the product description.
Appearance can vary. The stated peptide content is checked through third-party analysis.
Read more in the product description.
Solution not bundled
Peptides are delivered as lyophilized powder. This dry form helps preserve peptide quality during storage and transport and does not require refrigerated shipping during normal transit.
To prepare a solution, use a solvent such as Bacteriostatic water. It is sold separately, so add it only when you need it for peptide preparation.
Read more in the product description.
Cytoskeletal signalling peptide
TB-500
Low stock
TB-500 is Adria Science's complete 43-residue thymosin beta-4 peptide. Published studies look at actin binding, cell movement, blood-vessel models, nerve research, and microbial tests.
Order within — · ships today Cutoff 10:00 · local time
Arrives Sep 21 - Sep 23 to Europe
TB-500
49,90 €
Thymosin beta-4 style peptide for actin, cell-migration, and matrix studies.
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Research overview
TB-500
TB-500 is the complete 43-residue thymosin beta-4 sequence, not a short fragment. Its full sequence, product form, and lot results are shown in the product specifications and signed analytical records.
Studies cover full-length thymosin beta-4 in actin, vascular, nerve, microbial, and cardiovascular models. These papers provide research context, not a promised product result.
Actin organisation and cell movement
Studies identify thymosin beta-4 as an actin-binding peptide. They measure cytoskeleton organisation, cell movement, and cell development.
This work uses full-length thymosin beta-4, matching the complete 43-amino-acid identity of this Adria product.
Vascular, neural, and microbial models
Other studies use blood-vessel, nerve, cardiovascular, hair-follicle, and microbial models. These are separate research areas and should not be combined into one broad claim.
Compound information
Specifications
Molecular profile
- Sequence
- Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
- Molecular mass
- 4963.49 g/mol
- CAS number
- 77591-33-4
- Molecular formula
- C212H350N56O78S
Material record
- Physical appearance
- White to off-white lyophilized powder
- Solubility
- Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
- Product note
- Full-length 43-amino-acid thymosin beta-4, identified as TB-500 in the Adria Science analytical record; supplied strictly for research use only.
Laboratory care
Handling
Peptides in transport
Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.
Storage of lyophilized peptides
Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:
- Room temperature (15–25 °C): Up to 3 months
- Refrigerated (2–8 °C): Up to 6 months
- Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)
Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.
Storage of reconstituted peptides
Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.
The following storage conditions are generally recommended:
- Room temperature (15–25 °C): Avoid prolonged storage
- Refrigerated (2–8 °C): Typically 4–8 weeks
- Frozen (-20 °C or below): Up to 3–4 months
To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.
Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.
Analytical documentation
Latest test results
Latest published result
Liquilabs s.r.o.Signed Certificate of Analysis · 10mg
98.6%Purity by HPLC
Recorded QC panel
- AssayPeptide screening
- 12.38 mg
- PurityPeptide screening
- 98.6%
- Identity (FTIR)FTIR spectrum
- 994
- Identity (RT)Retention time
- 0.990
These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.
Source record
References
National Center for Biotechnology Information
PubChem Compound Summary: Thymosin beta 4
Authoritative identity record for the thymosin-beta-4 research context of TB-500.
PubChem · View source ↗Bock-Marquette I, Saxena A, White MD, et al. · 2004
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Primary work on full-length thymosin beta-4 in a cell-migration model.
Nature · 10.1038/nature03000 View source ↗Smart N, Risebro CA, Melville AA, et al. · 2007
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
Primary work on full-length thymosin beta-4 in an experimental developmental model.
Nature · 10.1038/nature05383 View source ↗Chemical Abstracts Service
CAS Common Chemistry: 77591-33-4
Authoritative CAS Registry Number record for full-length thymosin beta-4 context.
CAS Common Chemistry · View source ↗Ho ENM, Kwok WH, Lau MY, et al. · 2012
Doping control analysis of TB-500, a synthetic version of an active region of thymosin beta 4, in equine urine and plasma by liquid chromatography-mass spectrometry
Primary analytical report identifying one TB-500 preparation as N-acetylated LKKTETQ; it is shown to document the identity conflict, not to assert the sold vial form.
Journal of Chromatography A · 10.1016/j.chroma.2012.09.043 View source ↗Goldstein AL, Hannappel E, Sosne G, Kleinman HK · 2012
Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
Expert opinion on biological therapy · View source ↗Ruff D, Crockford D, Girardi G, Zhang Y · 2010
A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers
Annals of the New York Academy of Sciences · View source ↗Morris DC, Cui Y, Cheung WL, Lu M, Zhang L, Zhang ZG, Chopp M · 2014
A dose-response study of thymosin β4 for the treatment of acute stroke
Journal of the neurological sciences · View source ↗Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK · 1999
Thymosin beta4 accelerates wound healing
The Journal of investigative dermatology · View source ↗Xing Y, Ye Y, Zuo H, Li Y · 2021
Progress on the Function and Application of Thymosin β4
Frontiers in endocrinology · View source ↗Sosne G, Ousler GW · 2015
Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) model
Clinical ophthalmology (Auckland, N.Z.) · View source ↗Morris DC, Chopp M, Zhang L, Lu M, Zhang ZG · 2010
Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke
Neuroscience · View source ↗Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, Chopp M · 2011
Treatment of traumatic brain injury with thymosin β₄ in rats
Journal of neurosurgery · View source ↗· 2012
A. L. Goldstein et al., „Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications“, 2012 Jan;12(1):37-51
·P. Cheng, F. Kuang, H. Zhang, G. Ju, and J. Wang · 2014
Beneficial effects of thymosin β4 on spinal cord injury in the rat
Neuropharmacology ·M. Chopp and Z. G. Zhang · 2015
Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases
Expert Opin. Biol. Ther ·H. Li, Y. Wang, X. Hu, B. Ma, and H. Zhang · 2019
Thymosin beta 4 attenuates oxidative stress-induced injury of spinal cord-derived neural stem/progenitor cells through the TLR4/MyD88 pathway
Gene ·K. N. Dubé and N. Smart · 2018
Thymosin β4 and the vasculature: multiple roles in development, repair and protection against disease
Expert Opin. Biol. Ther ·D. Philp, S. St-Surin, H.-J. Cha, H.-S. Moon, H. K. Kleinman, and M. Elkin · 2007
Thymosin beta 4 induces hair growth via stem cell migration and differentiation
Ann. N. Y. Acad. Sci ·T. W. Carion et al. · 2018
Thymosin Beta-4 and Ciprofloxacin Adjunctive Therapy Improves Pseudomonas aeruginosa-Induced Keratitis
Cells ·K. M. Kassem, S. Vaid, H. Peng, S. Sarkar, and N.-E. Rhaleb · 2019
Tβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?
Can. J. Physiol. Pharmacol ·A. D. Shaghiera, P. Widiyanti, and H. Yusuf · 2018
Synthesis and Characterization of Injectable Hydrogels with Varying Collagen–Chitosan–Thymosin β4 Composition for Myocardial Infarction Therapy
J. Funct. Biomater ·H.-J. Han, S. Kim, and J. Kwon · 2018
Thymosin beta 4-Induced Autophagy Increases Cholinergic Signaling in PrP (106-126)-Treated HT22 Cells
Neurotox. Res., Dec. 2018. [PubMed] ·· 2012
Song, Ran & Choi, Hyun & Yang, Hyung-In & Yoo, Myung & Park, Yong-Beom & Kim, Kyoung. (2012). Association between serum thymosin β4 levels of rheumatoid arthritis patients and disease activity and response to therapy. Clinical rheumatology. 31. 1253-8. 10.1007/s10067-012-2011-7. [Research Gate]
· 10.1007/s10067-012-2011-7 View source ↗Philp, D., et al. · 2004



