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Peptide appearance Lyophilized form

Cytoskeletal signalling peptide

TB-500

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TB-500 is Adria Science's complete 43-residue thymosin beta-4 peptide. Published studies look at actin binding, cell movement, blood-vessel models, nerve research, and microbial tests.

Available strengths
49,90 
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TB-500

49,90 

Thymosin beta-4 style peptide for actin, cell-migration, and matrix studies.

SKU: ADRIA-TB-500 Category:

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Research overview

TB-500

TB-500 is the complete 43-residue thymosin beta-4 sequence, not a short fragment. Its full sequence, product form, and lot results are shown in the product specifications and signed analytical records.

Studies cover full-length thymosin beta-4 in actin, vascular, nerve, microbial, and cardiovascular models. These papers provide research context, not a promised product result.

Actin organisation and cell movement

Studies identify thymosin beta-4 as an actin-binding peptide. They measure cytoskeleton organisation, cell movement, and cell development.

This work uses full-length thymosin beta-4, matching the complete 43-amino-acid identity of this Adria product.

Vascular, neural, and microbial models

Other studies use blood-vessel, nerve, cardiovascular, hair-follicle, and microbial models. These are separate research areas and should not be combined into one broad claim.

Compound information

Specifications

Molecular profile

Sequence
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Molecular mass
4963.49 g/mol
CAS number
77591-33-4
Molecular formula
C212H350N56O78S

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Full-length 43-amino-acid thymosin beta-4, identified as TB-500 in the Adria Science analytical record; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 10mg

98.6%Purity by HPLC

Batch number
2025289
Tested
2026-05-28

Recorded QC panel

AssayPeptide screening
12.38 mg
PurityPeptide screening
98.6%
Identity (FTIR)FTIR spectrum
994
Identity (RT)Retention time
0.990

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: Thymosin beta 4

Authoritative identity record for the thymosin-beta-4 research context of TB-500.

PubChem · View source ↗

Bock-Marquette I, Saxena A, White MD, et al. · 2004

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

Primary work on full-length thymosin beta-4 in a cell-migration model.

Nature · 10.1038/nature03000 View source ↗

Smart N, Risebro CA, Melville AA, et al. · 2007

Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization

Primary work on full-length thymosin beta-4 in an experimental developmental model.

Nature · 10.1038/nature05383 View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 77591-33-4

Authoritative CAS Registry Number record for full-length thymosin beta-4 context.

CAS Common Chemistry · View source ↗

Ho ENM, Kwok WH, Lau MY, et al. · 2012

Doping control analysis of TB-500, a synthetic version of an active region of thymosin beta 4, in equine urine and plasma by liquid chromatography-mass spectrometry

Primary analytical report identifying one TB-500 preparation as N-acetylated LKKTETQ; it is shown to document the identity conflict, not to assert the sold vial form.

Journal of Chromatography A · 10.1016/j.chroma.2012.09.043 View source ↗

Goldstein AL, Hannappel E, Sosne G, Kleinman HK · 2012

Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications

Expert opinion on biological therapy · View source ↗

Ruff D, Crockford D, Girardi G, Zhang Y · 2010

A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers

Annals of the New York Academy of Sciences · View source ↗

Morris DC, Cui Y, Cheung WL, Lu M, Zhang L, Zhang ZG, Chopp M · 2014

A dose-response study of thymosin β4 for the treatment of acute stroke

Journal of the neurological sciences · View source ↗

Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK · 1999

Thymosin beta4 accelerates wound healing

The Journal of investigative dermatology · View source ↗

Xing Y, Ye Y, Zuo H, Li Y · 2021

Progress on the Function and Application of Thymosin β4

Frontiers in endocrinology · View source ↗

Sosne G, Ousler GW · 2015

Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) model

Clinical ophthalmology (Auckland, N.Z.) · View source ↗

Morris DC, Chopp M, Zhang L, Lu M, Zhang ZG · 2010

Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke

Neuroscience · View source ↗

Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, Chopp M · 2011

Treatment of traumatic brain injury with thymosin β₄ in rats

Journal of neurosurgery · View source ↗

· 2012

A. L. Goldstein et al., „Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications“, 2012 Jan;12(1):37-51

·

P. Cheng, F. Kuang, H. Zhang, G. Ju, and J. Wang · 2014

Beneficial effects of thymosin β4 on spinal cord injury in the rat

Neuropharmacology ·

M. Chopp and Z. G. Zhang · 2015

Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases

Expert Opin. Biol. Ther ·

H. Li, Y. Wang, X. Hu, B. Ma, and H. Zhang · 2019

Thymosin beta 4 attenuates oxidative stress-induced injury of spinal cord-derived neural stem/progenitor cells through the TLR4/MyD88 pathway

Gene ·

K. N. Dubé and N. Smart · 2018

Thymosin β4 and the vasculature: multiple roles in development, repair and protection against disease

Expert Opin. Biol. Ther ·

D. Philp, S. St-Surin, H.-J. Cha, H.-S. Moon, H. K. Kleinman, and M. Elkin · 2007

Thymosin beta 4 induces hair growth via stem cell migration and differentiation

Ann. N. Y. Acad. Sci ·

T. W. Carion et al. · 2018

Thymosin Beta-4 and Ciprofloxacin Adjunctive Therapy Improves Pseudomonas aeruginosa-Induced Keratitis

Cells ·

K. M. Kassem, S. Vaid, H. Peng, S. Sarkar, and N.-E. Rhaleb · 2019

Tβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?

Can. J. Physiol. Pharmacol ·

A. D. Shaghiera, P. Widiyanti, and H. Yusuf · 2018

Synthesis and Characterization of Injectable Hydrogels with Varying Collagen–Chitosan–Thymosin β4 Composition for Myocardial Infarction Therapy

J. Funct. Biomater ·

H.-J. Han, S. Kim, and J. Kwon · 2018

Thymosin beta 4-Induced Autophagy Increases Cholinergic Signaling in PrP (106-126)-Treated HT22 Cells

Neurotox. Res., Dec. 2018. [PubMed] ·

· 2012

Song, Ran & Choi, Hyun & Yang, Hyung-In & Yoo, Myung & Park, Yong-Beom & Kim, Kyoung. (2012). Association between serum thymosin β4 levels of rheumatoid arthritis patients and disease activity and response to therapy. Clinical rheumatology. 31. 1253-8. 10.1007/s10067-012-2011-7. [Research Gate]

· 10.1007/s10067-012-2011-7 View source ↗

Philp, D., et al. · 2004

Thymosin β4 Promotes Angiogenesis, Wound Healing, and Hair Follicle Development

Mechanisms of Ageing and Development · 10.1016/j.mad.2003.11.005 View source ↗

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