Peptide appearance
Lyophilized form helps protect peptide quality. Peptides are supplied as a dry powder, which may look like a compact "puck" or a lighter powder inside the vial.
Because the peptide is dry, it does not require refrigerated shipping during normal transit, including warm seasonal conditions. For longer storage, follow the storage guidance in the product description.
Appearance can vary. The stated peptide content is checked through third-party analysis.
Read more in the product description.
Solution not bundled
Peptides are delivered as lyophilized powder. This dry form helps preserve peptide quality during storage and transport and does not require refrigerated shipping during normal transit.
To prepare a solution, use a solvent such as Bacteriostatic water. It is sold separately, so add it only when you need it for peptide preparation.
Read more in the product description.
Neuroscience Research
Semax
Low stock
Semax is a synthetic ACTH-fragment analogue with a Pro-Gly-Pro extension. Published studies look at neurotrophin markers, gene expression, brain-ischaemia models, and cognitive tasks.
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Arrives 5 – 9 November to Europe
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Semax
44,50 €
ACTH-fragment analogue for neuropeptide, BDNF, and stress-pathway studies.
Research overview
Semax
Semax combines an ACTH(4-7)-based core with a short end sequence. This defined structure supports studies of peptide stability and nerve-cell signalling.
Studies cover brain-related markers, gene activity, ischaemia models, cognitive tasks, and stress responses. These are research settings, not a promised product result.
Gene expression and neurotrophin markers
Studies measure BDNF-related and other gene-expression changes in neural systems. These endpoints help researchers compare how study conditions affect signalling.
Other work maps brain connections and measures behaviour. Each result stays tied to the model used.
Cerebral and cognitive models
Published work also uses cerebral-ischaemia, cognitive-task, and stress models. The original study design, timing, and comparison group are needed for interpretation.
Compound information
Specifications
Molecular profile
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular mass
- 813.92 g/mol
- CAS number
- 80714-61-0
- Molecular formula
- C37H51N9O10S
Material record
- Physical appearance
- White to off-white lyophilized powder
- Solubility
- Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
- Product note
- ACTH(4-10) analogue heptapeptide; supplied strictly for research use only.
Laboratory care
Handling
Peptides in transport
Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.
Storage of lyophilized peptides
Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:
- Room temperature (15–25 °C): Up to 3 months
- Refrigerated (2–8 °C): Up to 6 months
- Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)
Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.
Storage of reconstituted peptides
Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.
The following storage conditions are generally recommended:
- Room temperature (15–25 °C): Avoid prolonged storage
- Refrigerated (2–8 °C): Typically 4–8 weeks
- Frozen (-20 °C or below): Up to 3–4 months
To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.
Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.
Analytical documentation
Tests
Latest published result
Liquilabs s.r.o.Signed Certificate of Analysis · 10mg
99.6%Purity by HPLC
Recorded QC panel
- AssayPeptide screening
- 12.46 mg
- PurityPeptide screening
- 99.6%
- Identity (FTIR)FTIR spectrum
- 998
- Identity (RT)Retention time
- 0.983
These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.
Source record
References
National Center for Biotechnology Information
PubChem Compound Summary: Semax
Authoritative identity record for Semax.
PubChem · View source ↗Panikratova YR, Lebedeva IS, Sokolov OY, et al. · 2020
Functional Connectomic Approach to Studying Selank and Semax Effects
Experimental comparison of Selank and Semax in a functional-connectomics model.
Doklady Biological Sciences · 10.1134/s001249662001007x View source ↗Chemical Abstracts Service
CAS Common Chemistry: 80714-61-0
Authoritative CAS Registry Number record for Semax.
CAS Common Chemistry · View source ↗National Center for Biotechnology Information
PubChem compound record
PubChem · View source ↗Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J · 2006
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Brain research · View source ↗Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV · 2014
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
BMC genomics · View source ↗Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN · 2018
[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · View source ↗Shadrina M, Kolomin T, Agapova T, Agniullin Y, Shram S, Slominsky P, Lymborska S, Myasoedov N · 2010
Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action
Journal of molecular neuroscience : MN · View source ↗Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Sudarkina OY, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV · 2020
Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats
Genes · View source ↗I. S. Lebedeva et al. · 2018
Effects of Semax on the Default Mode Network of the Brain
Bull. Exp. Biol. Med ·R. B. Mars, F.-X. Neubert, M. P. Noonan, J. Sallet, I. Toni, and M. F. S. Rushworth · 2012
On the relationship between the 'default mode network' and the 'social brain,'
Front. Hum. Neurosci ·T. I. Agapova et al. · 2008
[Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]
Mol. Genet. Mikrobiol. Virusol ·M. H. Scantlebury, K.-C. Chun, S.-C. Ma, J. M. Rho, and D. Y. Kim · 2017
Adrenocorticotropic Hormone Protects Learning and Memory Function in Epileptic Kcna1-null mice
Neurosci. Lett ·T. Deltheil et al. · 2008
Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice
Neuropharmacology ·· 2017
Ivanov, Alexander & Bobyntsev, Igor & Shepeleva, Olga & Kryukov, Alexey & Andreeva, L & Myasoedov, N. (2017). Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress. Bulletin of experimental biology and medicine. 163. [Research Gate]
·· 2015
Bobyntsev, Igor & Kryukov, Alexey & Shepeleva, Olga & Ivanov, Alexander. (2015). The effect of ACTH-4-7-PGP peptide on lipid peroxidation in liver and activity of serum transaminases in rats under acute and chronic immobilization stress conditions. 78. 18-21. [Research Gate]
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