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Peptide appearance Lyophilized form

Mitochondrial peptide

MOTSC

In stock

MOTS-c is a peptide encoded in the mitochondrial 12S rRNA region. Published studies look at cellular energy, glucose, lipids, muscle, bone, and cardiovascular models.

Available strengths
148,50 
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MOTSC

Price range: 49,90 € through 148,50 €

Mitochondrial-derived peptide for cellular energy and stress-signalling studies.

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Research overview

MOTSC

MOTS-c is a short mitochondrial-derived peptide linked to MT-RNR1. Its mitochondrial origin makes it useful for studying cell communication and metabolic signals.

Studies cover exercise metabolism, insulin signals, mitochondrial stress, bone models, and cardiovascular observations. These reports provide research context, not a product result.

Mitochondrial and metabolic signalling

Studies measure AMPK-related signals, glucose use, lipid metabolism, and skeletal-muscle endpoints. Each result depends on the original laboratory system.

Other work looks at mitochondrial stress and changes in nuclear gene expression.

Muscle, bone, and cardiovascular models

Published work also covers exercise, bone, longevity, and cardiovascular models. These study types and their endpoints should be considered separately.

Compound information

Specifications

Molecular profile

Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular mass
2174.60 g/mol
CAS number
1627580-64-6
Molecular formula
C101H152N28O22S2

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Mitochondrial-derived 16-amino-acid peptide; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 40mg

99.7%Purity by HPLC

Batch number
20262310
Tested
2026-05-28

Recorded QC panel

AssayPeptide screening
40.5 mg
PurityPeptide screening
99.7%
Identity (FTIR)FTIR spectrum
1000
Identity (RT)Retention time
0.986

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: MOTS-c

Authoritative identity record for the mitochondrial-derived peptide MOTS-c.

PubChem · View source ↗

Lee C, Zeng J, Drew BG, et al. · 2015

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Primary report identifying MOTS-c as a mitochondrial-derived peptide.

Cell Metabolism · 10.1016/j.cmet.2015.02.009 View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 1627580-64-6

Authoritative CAS Registry Number record for MOTS-c.

CAS Common Chemistry · View source ↗

National Center for Biotechnology Information

NCBI Gene: MT-RNR1 mitochondrial 12S rRNA

Authoritative gene record for the mitochondrial transcript that encodes MOTS-c.

NCBI Gene · View source ↗

Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N · 2015

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

Aging cell · View source ↗

Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P · 2019

The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity

Physiological reports · View source ↗

Y. Zheng et al. · 2023

MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation

2023 ·

C. Lee, K. H. Kim, and P. Cohen · 2016

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

Free Radic. Biol. Med ·

H. Lu et al. · 2019

MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction

J. Mol. Med. Berl. Ger ·

K. H. Kim, J. M. Son, B. A. Benayoun, and C. Lee · 2018

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

Cell Metab ·

R. Crescenzo, F. Bianco, A. Mazzoli, A. Giacco, G. Liverini, and S. Iossa · 2016

A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance

Eur. J. Nutr ·

L. R. Cataldo, R. Fernández-Verdejo, J. L. Santos, and J. E. Galgani · 2018

Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals

J. Investig. Med ·

N. Che et al. · 2019

MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts via TGF-β/SMAD signaling pathway

Eur. Rev. Med. Pharmacol. Sci ·

B.-T. Hu and W.-Z. Chen · 2018

MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway

Eur. Rev. Med. Pharmacol. Sci ·

Q. Qin et al. · 2018

Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction

Int. J. Cardiol ·

Y. Yang et al. · 2019

The role of mitochondria-derived peptides in cardiovascular disease: Recent updates

Biomed. Pharmacother. Biomedecine Pharmacother ·

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