Buy 2, save 5%Buy 3+, save 9%Buy 6+, save 15%Buy 10+, save 22%Free EU & Balkan shipping over €1503rd-party tested batchesTest results available through the libraryCzech Republic fulfillmentResearch use onlyBuy 2, save 5%Buy 3+, save 9%Buy 6+, save 15%Buy 10+, save 22%Free EU & Balkan shipping over €1503rd-party tested batchesTest results available through the libraryCzech Republic fulfillmentResearch use only
Lyophilized form helps protect peptide quality. Peptides are supplied as a dry powder, which may look like a compact "puck" or a lighter powder inside the vial.
Because the peptide is dry, it does not require refrigerated shipping during normal transit, including warm seasonal conditions. For longer storage, follow the storage guidance in the product description.
Appearance can vary. The stated peptide content is checked through third-party analysis.
Read more in the product description.
Solution not bundled
Peptides are delivered as lyophilized powder. This dry form helps preserve peptide quality during storage and transport and does not require refrigerated shipping during normal transit.
To prepare a solution, use a solvent such as Bacteriostatic water. It is sold separately, so add it only when you need it for peptide preparation.
Read more in the product description.
Melanocortin research peptide
Melanotan II
In stock
Melanotan II is a cyclic alpha-MSH analogue used in melanocortin-receptor research. Published studies look at receptor binding, pigment-cell signals, food-intake measurements, and behaviour models.
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39,00 €39,00 €
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Melanotan II · 1 vial139,00 €39,00 €
Melanotan II
39,00 €
Cyclic melanocortin analogue for receptor selectivity and pigmentation-pathway studies.
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Research overview
Melanotan II
Melanotan II is a cyclic synthetic peptide, not linear alpha-MSH. Its ring-shaped structure matters in receptor and structure-activity comparisons.
Studies cover melanocortin receptors, pigment cells, food-intake endpoints, and behaviour tests. Each finding applies only to the experimental system used.
Melanocortin-receptor studies
Studies compare binding and signalling across melanocortin-receptor types. This work helps researchers examine how a cyclic peptide's structure affects receptor activity.
Pigment-related experiments are receptor-system observations, not a product outcome.
Behavioural and metabolic endpoints
Other studies measure food intake, alcohol intake, and metabolic endpoints. The original model, protocol, and controls are needed to understand these results.
Compound information
Specifications
Molecular profile
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Molecular mass
1024.18 g/mol
CAS number
121062-08-6
Molecular formula
C50H69N15O9
Material record
Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Synthetic cyclic melanocortin analogue; supplied strictly for research use only.
Laboratory care
Handling
Peptides in transport
Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.
Storage of lyophilized peptides
Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:
Room temperature (15–25 °C): Up to 3 months
Refrigerated (2–8 °C): Up to 6 months
Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)
Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.
Storage of reconstituted peptides
Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.
The following storage conditions are generally recommended:
Room temperature (15–25 °C): Avoid prolonged storage
Refrigerated (2–8 °C): Typically 4–8 weeks
Frozen (-20 °C or below): Up to 3–4 months
To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.
Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.
Analytical documentation
Latest test results
Latest published result
Liquilabs s.r.o.Signed Certificate of Analysis · 10mg
99.6%Purity by HPLC
Batch number
2210277
Tested
2026-07-27
Recorded QC panel
AssayPeptide screening
12.22 mg
PurityPeptide screening
99.6%
Identity (FTIR)FTIR spectrum
998
Identity (RT)Retention time
0.994
Bacterial EndotoxinUSP / Eur. Ph. 2.6.14
0.023 EU/mg
Molecular Ion MassMS deconvolution
1024 Da
These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.
An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonistDiamond LE, et al
International Journal of Impotence Research ·
View source ↗
E. Minakova et al. · 2019
Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism
PLoS ONE ·
A. van der Klaauw et al. · 2015
Role of melanocortin signalling in the preference for dietary macronutrients in human beings
Lancet Lond. Engl ·
H. Shimizu, K. Inoue, and M. Mori · 2007
The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure
J. Endocrinol ·
C. Bjørbaek and A. N. Hollenberg · 2002
Leptin and melanocortin signaling in the hypothalamus
Vitam. Horm ·
F. Guo, K. Bakal, Y. Minokoshi, and A. N. Hollenberg · 2004
Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo
Endocrinology ·
Y. H. Lee, M.-Y. Wang, X.-X. Yu, and R. H. Unger · 2016
GCG is the key factor in the development of diabetes
Diabetologia ·
C. Toda et al. · 2009
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues
Diabetes ·
D. A. York, S. Boghossian, and M. Park-York · 2011
Melanocortin activity in the amygdala influences alcohol intake
Pharmacol. Biochem. Behav ·
M. Navarro, F. Carvajal, J. M. Lerma-Cabrera, I. Cubero, M. J. Picker, and T. E. Thiele · 2015
Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice
Alcohol. Clin. Exp. Res ·
· 2003
WESSELLS, H. , HRUBY, V. J., HACKETT, J. , HAN, G. , BALSE‐SRINIVASAN, P. and VANDERAH, T. W. (2003), MT‐II Induces Penile Erection via Brain and Spinal Mechanisms. Annals of the New York Academy of Sciences, 994: 90-95
·
· 1998
Wessells, H. (1998). Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Doubleblind placebo controlled crossover study. Nature.com. Available at
·
M. T. Islam et al. · 2022
Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons
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