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BPC-157
Peptide appearance Lyophilized form

Signalling peptide

BPC-157

In stock

BPC-157 is a synthetic peptide made of 15 amino acids. Published studies look at fibroblasts, extracellular matrix, blood-vessel signalling, and cell movement.

Available strengths
51,50 
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BPC-157

51,50 

BPC-157 reference peptide for tissue-signalling, gut-barrier, and repair-pathway models.

SKU: ADRIA-BPC-157 Categories: ,

Research overview

BPC-157

BPC-157 is a defined 15-amino-acid peptide. Its sequence, form, and lot-specific test results should be checked directly.

Studies cover connective-tissue, vascular, cell-protection, and oxidative-stress models. They identify research questions but do not promise a result for this product.

Fibroblast and matrix models

Studies measure fibroblast activity, collagen, cell growth, re-epithelialisation, and ERK1/2 signalling in laboratory models. Each observation applies only to the system used in the paper.

Other studies look at tendon, muscle, ligament, and bone models, with a focus on cell movement and extracellular-matrix organisation.

Vascular and cell-protection questions

Published work also looks at endothelial cells, blood-vessel development, nitric-oxide signals, and oxidative stress. The original model and method are needed to understand each result.

Compound information

Specifications

Molecular profile

Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular mass
1419.54 g/mol
CAS number
137525-51-0
Molecular formula
C62H98N16O22

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Synthetic pentadecapeptide; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Tests

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 10mg

99.5%Purity by HPLC

Batch number
2025297
Tested
2026-05-28

Recorded QC panel

AssayPeptide screening
12.45 mg
PurityPeptide screening
99.5%
Identity (FTIR)FTIR spectrum
997
Identity (RT)Retention time
0.982

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: BPC-157

Authoritative identity record for BPC-157.

PubChem · View source ↗

Chang CH, Tsai WC, Lin MS, et al. · 2011

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration

Primary BPC-157 study in a defined experimental tendon model.

Journal of Applied Physiology · 10.1152/japplphysiol.00945.2010 View source ↗

Krivic A, Anic T, Seiwerth S, et al. · 2006

Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation

Primary BPC-157 study in a defined rat tendon-to-bone model.

Journal of Orthopaedic Research · 10.1002/jor.20096 View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 137525-51-0

Authoritative CAS Registry Number record for BPC-157.

CAS Common Chemistry · View source ↗

National Center for Biotechnology Information

PubChem compound record

PubChem · View source ↗

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM · 2025

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

HSS journal : the musculoskeletal journal of Hospital for Special Surgery · View source ↗

Xu C, Sun L, Ren F, Huang P, Tian Z, Cui J, Zhang W, Wang S, Zhang K, He L, Zhang W, Zhang C, Hao Q, Zhang Y, Li M, Li W · 2020

Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds

Regulatory toxicology and pharmacology : RTP · View source ↗

Sikiric P, Seiwerth S, Rucman R, Kolenc D, Vuletic LB, Drmic D, Grgic T, Strbe S, Zukanovic G, Crvenkovic D, Madzarac G, Rukavina I, Sucic M, Baric M, Starcevic N, Krstonijevic Z, Bencic ML, Filipcic I, Rokotov DS, Vlainic J · 2016

Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications

Current neuropharmacology · View source ↗

Vukojevic J, Milavić M, Perović D, Ilić S, Čilić AZ, Đuran N, Štrbe S, Zoričić Z, Filipčić I, Brečić P, Seiverth S, Sikirić P · 2022

Pentadecapeptide BPC 157 and the central nervous system

Neural regeneration research · View source ↗

Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS · 2017

Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation

Journal of molecular medicine (Berlin, Germany) · View source ↗

Sebecić B, Nikolić V, Sikirić P, Seiwerth S, Sosa T, Patrlj L, Grabarević Z, Rucman R, Petek M, Konjevoda P, Jadrijević S, Perović D, Slaj M · 1999

Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation

Bone · View source ↗

Lee E, Burgess K · 2025

Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study

Alternative therapies in health and medicine · View source ↗

· 2018

BPC-157 enhances growth hormone receptor expression in injured tendon tissueStaresinic M, Sebecic B, et al

Growth Hormone & IGF Research · View source ↗

T. Huang et al. · 2015

Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

Drug Des. Devel. Ther ·

Chung-Hsun Chang et al.

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

·

3D. Drmic et al. · 2018

Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine

World J. Gastroenterol ·

F. Amic et al. · 2018

Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine

World J. Gastroenterol ·

J. Vukojević et al. · 2018

Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157

Vascul. Pharmacol ·

D. Drmic et al. · 2017

Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

World J. Gastroenterol ·

Z. Grabarevic et al. · 1997

The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks

J. Physiol. Paris ·

P. Sikiric et al. · 1990

Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing

Curr. Pharm. Des ·

S. Seiwerth et al. · 1972

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing

Curr. Pharm. Des ·

Y.-L. Hu et al. · 2014

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells

Sci. Rep ·

K. Škrlec et al. · 2018

Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities

Appl. Microbiol. Biotechnol ·

D. Strinic et al. · 2017

BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats

Life Sci ·

N. Jelovac et al. · 1999

Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats

Eur. J. Pharmacol ·

Tlak Gajger, J. Ribarić, M. Smodiš Škerl, J. Vlainić, and P. Sikirić · 2018

Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions

J. Vet. Pharmacol. Ther ·

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