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Peptide appearance Lyophilized form

Growth-hormone fragment analogue

AOD9604

In stock

AOD-9604 is a synthetic 15-amino-acid fragment from the 176–191 region of growth hormone. Published studies look at fat-cell signalling, cartilage cells, and cardiovascular laboratory models.

Available strengths
60,00 
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AOD9604

60,00 

AOD9604 hGH fragment analogue for structure-function and metabolic pathway studies.

SKU: ADRIA-AOD9604 Category: Tag:

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Research overview

AOD9604

AOD-9604 is a defined peptide fragment, not full-length growth hormone. Its exact sequence and the study method are important when comparing published findings.

Studies cover fat-tissue signalling, cartilage-cell models, and cardiovascular observations. Each finding applies only to the model and method used in that study.

Lipid-signalling models

Studies measure fat-tissue metabolism, beta-3 adrenergic receptors, and fat-breakdown signals in laboratory models. The meaning of each result depends on the model, comparison group, and test method.

Other studies compare this fragment with related growth-hormone materials. They help researchers study how changes in structure affect laboratory measurements.

Cartilage and cardiovascular observations

Published work also covers cartilage cells and cardiovascular models. These findings should be read only within the original study conditions.

Compound information

Specifications

Molecular profile

Sequence
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide Cys7-Cys14)
Molecular mass
1815.1 g/mol
CAS number
221231-10-3
Molecular formula
C78H123N23O23S2

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Synthetic hGH fragment analogue; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 5mg

Certificate preview for 5mg

99.2%Purity by HPLC

Batch number
2247231
Tested
2026-09-08

Recorded QC panel

AssayPeptide Screening 0.1% TFA
5.58 mg (± 0.03 mg)
PurityPeptide Screening 0.1% TFA
99.2%
Identity (spectrum)Peptide Screening 0.1% TFA
979 (± 5)
Identity (RT)Retention time
0.998 (± 0.005)
Bacterial endotoxinUSP 85 / Eur. Ph. 2.6.14
0.138 EU/mg

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: AOD9604

Authoritative identity record for AOD9604.

PubChem · View source ↗

Cox HD, Smeal SJ, Hughes CM, et al. · 2015

Detection and in vitro metabolism of AOD9604

Primary analytical study of AOD9604.

Drug Testing and Analysis · 10.1002/dta.1715 View source ↗

Heffernan MA, Thorburn AW, Fam B, et al. · 2001

Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment

Primary experimental study of a modified growth-hormone C-terminal fragment.

International Journal of Obesity and Related Metabolic Disorders · 10.1038/sj.ijo.0801740 View source ↗

Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R · 2000

Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone

Hormone research · View source ↗

Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM · 2001

The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice

Endocrinology · View source ↗

H. Stier, E. Vos, and D. Kenley · 2013

Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans

J. Endocrinol. Metab ·

· 2004

Obesity drug codenamed AOD9604 highly successful in trials

·

M. Heffernan et al. · 2001

The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice

Endocrinology ·

D. R. Kwon and G. Y. Park · 2015

Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model

Ann. Clin. Lab. Sci ·

M. D. Jensen · 2006

Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors

Obes. Silver Spring Md ·

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