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Peptide appearance Lyophilized form

Metabolic small molecule

5-amino-1MQ

In stock

A quinolinium NNMT-inhibitor reference used in methylation and metabolism studies.

Available strengths
43,90 
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5-amino-1MQ

Price range: 43,90 € through 104,50 €

NNMT-focused small-molecule reference for metabolism and NAD-adjacent pathway studies.

SKU: ADRIA-5-AMINO-1MQ Category: Tag:

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Research overview

5-amino-1MQ

5-amino-1MQ is shorthand for 5-amino-1-methylquinolinium, a small-molecule research compound rather than a peptide.

Laboratory work examines nicotinamide N-methyltransferase inhibition, methylation chemistry, and NAD-adjacent metabolism. The listed sources are a research starting point rather than a substitute for product evidence: the supplied material's exact form, lot, and measured characteristics must be established through its signed analytical record.

Compound information

Specifications

Molecular profile

Molecular mass
286.11 g/mol
CAS number
42464-96-0
Molecular formula
C10H11IN2

Material record

Physical appearance
Yellow to brown powder or lyophilized solid
Salt form
Iodide salt
Solubility
Soluble in DMSO and suitable polar laboratory solvents.
Product note
Small-molecule NNMT inhibitor reference compound; studied in nicotinamide metabolism, methylation pathway, and cellular metabolism assays; supplied strictly for research use only.

Laboratory care

Handling

Product storage

Sealed dry material: store at -20 °C, desiccated and protected from light. Prepared solutions require a solvent-specific validated stability protocol.

Material in transport

Keep the sealed container dry, protected from direct light, and within the product-specific laboratory transport conditions.

Storage of dry material

Keep the sealed reference material protected from moisture and light and follow the product-specific storage record maintained by Adria Science.

Storage of prepared laboratory solutions

Prepared laboratory solutions require compatible solvent selection, clean handling, and a documented laboratory stability policy.

Analytical documentation

Latest test results

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 10mg

Certificate preview for 10mg

> 99.8%Purity by HPLC

Batch number
7392048
Tested
2026-09-08

Recorded QC panel

AssayPeptide Screening 0.1% TFA
12.40 mg (± 0.06 mg)
PurityPeptide Screening 0.1% TFA
> 99.8%
Identity (FTIR)Peptide Screening 0.1% TFA
996 (± 5)
Identity (RT)Retention time
0.998 (± 0.005)
Bacterial endotoxinUSP 85 / Eur. Ph. 2.6.14
0.286 EU/mg

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: 5-Amino-1-methylquinolinium

Authoritative identity record for 5-amino-1MQ.

PubChem · View source ↗

National Center for Biotechnology Information

NCBI Gene: NNMT nicotinamide N-methyltransferase

Authoritative gene record for the NNMT research target.

NCBI Gene · View source ↗

Kraus D, Yang Q, Kong D, et al. · 2014

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Primary NNMT-pathway study relevant to the compound's research target.

Nature · 10.1038/nature13198 View source ↗

Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ · 2017

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

Journal of medicinal chemistry · View source ↗

Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ · 2018

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

Biochemical pharmacology · View source ↗

Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ · 2019

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

Biochemical pharmacology · View source ↗

Sampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ · 2021

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

Scientific reports · View source ↗

Awosemo O, Neelakantan H, Watowich S, Ma J, Wu L, Chow DS, Liang D · 2021

Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies

Journal of pharmaceutical and biomedical analysis · View source ↗

Akar S, Duran T, Azzawri AA, Koçak N, Çelik Ç, Yıldırım Hİ · 2021

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · View source ↗

Dimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, Watowich S · 2022

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

Scientific reports · View source ↗

Babula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H · 2024

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction

Diabetes, obesity & metabolism · View source ↗

Customer reviews

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Great experience with Adria Science. Due to a minor delivery delay, they upgraded my order. Joey from customer support was helpful and…

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