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CJC - 1295 (no-DAC)
Peptide appearance Lyophilized form

GHRH analogue

CJC - 1295 (no-DAC)

In stock

CJC-1295 no DAC, also called modified GRF(1-29), is a synthetic GHRH analogue without a drug-affinity complex. Published studies look at analogue design, VIP-receptor interaction, and growth-hormone-response measurements.

Available strengths
80,50 
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CJC - 1295 (no-DAC)

Price range: 55,50 € through 80,50 €

Modified GRF(1-29) no-DAC peptide for GHRH receptor pathway studies.

SKU: ADRIA-CJC-1295-NO-DAC Categories: ,

Research overview

CJC - 1295 (no-DAC)

The no-DAC form is different from albumin-binding CJC-1295. Its modified GRF(1-29) sequence should be considered separately in receptor studies and analytical records.

Studies cover gastrointestinal receptors, metabolic models, and endocrine responses. These reports provide research context, not a promised product outcome.

Analogue design and receptor selectivity

Studies show how shortened GRF analogues and small amino-acid changes can affect clearance and receptor interaction. Other experiments measure VIP-receptor binding and adenylate-cyclase activity.

These comparisons show why small sequence changes can produce different laboratory readings.

Endocrine-response studies

Published work also measures growth-hormone responses in metabolic and thyroid-related models. The results belong to those study conditions, not to an individual product lot.

Compound information

Specifications

Molecular profile

Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Molecular mass
3367.9 g/mol
CAS number
446036-97-1
Molecular formula
C152H252N44O42

Material record

Physical appearance
White to off-white lyophilized powder
Solubility
Soluble in bacteriostatic water and suitable aqueous laboratory solvents.
Product note
Modified GRF(1-29) / CJC-1295 without DAC; supplied strictly for research use only.

Laboratory care

Handling

Peptides in transport

Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.

Storage of lyophilized peptides

Lyophilized peptides should be stored in a dry place, protected from light and moisture. The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Up to 3 months
  • Refrigerated (2–8 °C): Up to 6 months
  • Frozen (-20 °C or below): 3–5 years (recommended for long-term storage)

Allow the vial to reach room temperature after taking it out of the refrigerator or freezer.

Storage of reconstituted peptides

Once reconstituted, peptide solutions are generally less stable than their lyophilized form and should be stored under refrigerated conditions whenever possible.

The following storage conditions are generally recommended:

  • Room temperature (15–25 °C): Avoid prolonged storage
  • Refrigerated (2–8 °C): Typically 4–8 weeks
  • Frozen (-20 °C or below): Up to 3–4 months

To preserve peptide integrity, avoid repeated freeze–thaw cycles, as these may accelerate peptide degradation.

Important: Most manufacturers recommend discarding reconstituted peptides within 4 weeks when stored at 2–8 °C. This recommendation is intentionally conservative and may not reflect the actual chemical stability of every peptide. In our own stability studies, many peptides reconstituted in bacteriostatic water showed no detectable degradation after 12 weeks of refrigerated storage. As peptide stability is highly sequence- and formulation-dependent, this result should not be extrapolated to all peptides without supporting stability data.

Analytical documentation

Tests

Latest published result

Liquilabs s.r.o.Signed Certificate of Analysis · 10mg

Certificate preview for 10mg

99.3%Purity by HPLC

Batch number
2025295
Tested
2026-09-08

Recorded QC panel

AssayPeptide Screening 0.1% TFA
10.91 mg (± 0.05 mg)
PurityPeptide Screening 0.1% TFA
99.3%
Identity (FTIR)Peptide Screening 0.1% TFA
983 (± 5)
Identity (RT)Retention time
0.997 (± 0.005)
Bacterial endotoxinUSP 85 / Eur. Ph. 2.6.14
0.011 EU/mg

These are the latest published results for this strength. The batch number is printed on each vial. Your supplied batch is confirmed against the matching published record when your order is allocated.

See all test results

Signed certificate

Source record

References

National Center for Biotechnology Information

PubChem Compound Summary: CJC-1295

Authoritative identity record for the CJC-1295 peptide family.

PubChem · View source ↗

Teichman SL, Neale A, Lawrence B, et al. · 2006

Prolonged stimulation of growth hormone and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of growth hormone-releasing hormone, in healthy adults

Context for long-acting DAC CJC-1295 only; this paper does not establish the identity of the sold no-DAC material.

Journal of Clinical Endocrinology and Metabolism · 10.1210/jc.2005-1536 View source ↗

Chemical Abstracts Service

CAS Common Chemistry: 446036-97-1

Authoritative CAS Registry Number record for the no-DAC CJC-1295 free-peptide form.

CAS Common Chemistry · View source ↗

Sackmann-Sala L, Ding J, Frohman LA, et al. · 2009

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects

Context for long-acting DAC CJC-1295 only; this paper does not establish the identity of the sold no-DAC material.

Growth Hormone and IGF Research · 10.1016/j.ghir.2009.03.001 View source ↗

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA · 2006

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults

The Journal of clinical endocrinology and metabolism · View source ↗

Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH · 1998

Ipamorelin, the first selective growth hormone secretagogue

European journal of endocrinology · View source ↗

Shrestha P, Sabharwal G, Ghaffari G · 2018

A Novel STAT3 Gene Mutation Related Hyper-IgE Syndrome Misdiagnosed as Hidradenitis Suppurativa

Case reports in immunology · View source ↗

Sander HJ, Kramer P, van Leeuwen EC, van Cappellen WA, Meijs-Roelofs HM, De Jong FH · 1991

Ovulation rate, follicle population and FSH levels in cyclic rats after administration of an inhibin-neutralizing antiserum

The Journal of endocrinology · View source ↗

Kallio P, Murphy ED · 1998

Soluble CD27 in thyroid disorders

The Journal of laboratory and clinical medicine · View source ↗

Abiven G, Coste J, Groussin L, Anract P, Tissier F, Legmann P, Dousset B, Bertagna X, Bertherat J · 2006

Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients

The Journal of clinical endocrinology and metabolism · View source ↗

T. Ito et al. · 2001

GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity

Peptides ·

M. Waelbroeck, P. Robberecht, D. H. Coy, J.-C. Camus, P. D. Neef, and J. Christophe · 1985

Interaction of Growth Hormone-Releasing Factor (GRF) and 14 GRF Analogs with Vasoactive Intestinal Peptide (VIP) Receptors of Rat Pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(l-29)-NH2 as a VIP Antagonist

Endocrinology ·

A. V. Schally, X. Zhang, R. Cai, J. M. Hare, R. Granata, and M. Bartoli

Actions and potential therapeutic applications of growth hormone-releasing hormone agonists

Endocrinology ·

R. Valcavi et al. · 1986

Growth Hormone Responses to Grf 1–29 in Patients with Primary Hypothyroidism Before and During Replacement Therapy with Thyroxine

Clin. Endocrinol. (Oxf.) ·

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